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1

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

van der Velden, Jolanda, Stienen, Ger J. M.

Journal:

Physiological Reviews

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

2

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies

Ruud Zaremba, Daphne Merkus, Nazha Hamdani, Jos M. J. Lamers, Walter J. Paulus, Cris dos Remedios, Dirk J. Duncker, Ger J. M. Stienen, Jolanda van der Velden

Journal:

PROTEOMICS - Clinical Applications

Year:

2007

Language:

english

File:

PDF, 331 KB

english, 2007

3

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+sensitivity in human myocardium

Viola Kooij, Nicky Boontje, Ruud Zaremba, Kornelia Jaquet, Cris dos Remedios, Ger J. M. Stienen, Jolanda van der Velden

Journal:

Basic Research in Cardiology

Year:

2010

Language:

english

File:

PDF, 514 KB

english, 2010

4

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

Stephanie Reis, Christoph Littwitz, Sebastian Preilowski, Andreas Mügge, Ger J. M. Stienen, Lutz Pott, Kornelia Jaquet

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

5

Myocardial adaptations in the failing heart: cause or consequence?

Sabine J. van Dijk, Nazha Hamdani, Ger J. M. Stienen, Jolanda van der Velden

Journal:

Journal of Muscle Research and Cell Motility

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

6

A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients

Sabine J. van Dijk, Rozemarije A. Holewijn, Anouk Tebeest, Cris dos Remedios, Ger J. M. Stienen, Jolanda van der Velden

Journal:

Journal of Muscle Research and Cell Motility

Year:

2009

Language:

english

File:

PDF, 254 KB

english, 2009

7

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

Paul J. M. Wijnker, Peter Boknik, Ulrich Gergs, Frank U. Müller, Joachim Neumann, Cris dos Remedios, Wilhelm Schmitz, Jürgen R. Sindermann, Ger J. M. Stienen, Jolanda van der Velden, Uwe Kirchhefer

Journal:

Journal of Muscle Research and Cell Motility

Year:

2011

Language:

english

File:

PDF, 557 KB

english, 2011

8

More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease

Nazha Hamdani, Attila Borbély, Sophie P. G. R. Veenstra, Viola Kooij, Wim Vrydag, Ruud Zaremba, Cris dos Remedios, Hans W. M. Niessen, Martin C. Michel, Walter J. Paulus, Ger J. M. Stienen, Jolanda va

Journal:

Journal of Muscle Research and Cell Motility

Year:

2010

Language:

english

File:

PDF, 716 KB

english, 2010

9

The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart—detrimental or beneficial?

Viola Kooij, Ger J. M. Stienen, Jolanda van der Velden

Journal:

Biophysical Reviews

Year:

2011

Language:

english

File:

PDF, 222 KB

english, 2011

10

The development of familial hypertrophic cardiomyopathy: from mutation to bedside

Wessel P. Brouwer, Sabine J. van Dijk, Ger J. M. Stienen, Albert C. van Rossum, Jolanda van der Velden, Tjeerd Germans

Journal:

European Journal of Clinical Investigation

Year:

2011

Language:

english

File:

PDF, 301 KB

english, 2011

11

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium

Regis R. Lamberts, Nazha Hamdani, Tenoedj W. Soekhoe, Nicky M. Boontje, Ruud Zaremba, Lori A. Walker, Pieter P. De Tombe, Jolanda Van Der Velden, Ger J. M. Stienen

Journal:

The Journal of Physiology

Year:

2007

Language:

english

File:

PDF, 670 KB

english, 2007

12

Cooperative behavior of molecular motors

Karen C. Vermeulen, Ger J.M. Stienen, Christoph F. Schmidt

Journal:

Journal of Muscle Research and Cell Motility

Year:

2002

Language:

english

File:

PDF, 253 KB

english, 2002

13

Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts

R. Arthur Bouwman, M. Jumoke A. Vreden, Nazha Hamdani, Lisan E.J. Wassenaar, Lonneke Smeding, Stephan A. Loer, Ger J.M. Stienen, Regis R. Lamberts

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 990 KB

english, 2010

14

Optical trap stiffness in the presence and absence of spherical aberrations

Vermeulen, Karen C., Wuite, Gijs J. L., Stienen, Ger J. M., Schmidt, Christoph F.

Journal:

Year:

2006

Language:

english

File:

PDF, 749 KB

english, 2006

15

Why intact myocardium shows no Fenn effect

Gijs Elzinga, Zoltán Papp, Ger JM Stienen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 100 KB

english, 1992

16

Hyperosmolality enhances the rate of heat production of isolated, quiescent, right ventricular trabeculae of the rat

Denis S. Loiselle, Ger Stienen, Jürgen Daut, Gijs Elzinga

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 102 KB

english, 1992

17

Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2)

Coen A.C. Ottenheijm, Pleuni Hooijman, Elizabeth T. DeChene, Ger J. Stienen, Alan H. Beggs, Henk Granzier

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 923 KB

english, 2010

18

PKC catalytic subunit and phenylephrine induce a comparable decrease in myofilament calcium sensitivity

Judit Barta, Jolanda van der Velden, Nicky M. Boontje, Ruud Zaremba, Ger J.M. Stienen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 53 KB

english, 2007

19

Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background

Viola Kooij, Martina Saes, Kornelia Jaquet, Ruud Zaremba, D. Brian Foster, Anne M. Murphy, Cris dos Remedios, Jolanda van der Velden, Ger J.M. Stienen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

20

Myofilament Degradation and Dysfunction of Human Cardiomyocytes in Fabry Disease

Cristina Chimenti, Nazha Hamdani, Nicky M. Boontje, Francesco DeCobelli, Antonio Esposito, Jean G.F. Bronzwaer, Ger J.M. Stienen, Matteo A. Russo, Walter J. Paulus, Andrea Frustaci, Jolanda van der Ve

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 659 KB

english, 2008

21

Perturbed Length-Dependent Activation in Human HCM with Sarcomere Mutations in Thin Filament Proteins

Sequeira, Vasco, Regan, Jessica A., Michels, Michelle, ten Cate, Folkert J., van Slegtenhorst, Marjon A., Stienen, Ger J.M., dos Remedios, Cris, van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

22

Impact of Site Specific Phosphorylation of the Protein Kinase a Sites Ser23 and Ser24 of Cardiac Troponin I on Contractile Function in Human Cardiomyocytes

Wijnker, Paul J.M., Foster, D. Brian, Coulter, Allison, Frazier, Aisha, Murphy, Anne M., Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 40 KB

english, 2012

23

Reduced Length-Dependent Activation in Human Cardiomyocytes Harboring the Troponin I Mutation R145W

Regan, Jessica, Sequeira, Vasco, Stienen, Ger J.M., Michels, Michelle, ten Cate, Folkert J., van Slegtenhorst, Marjon, dos Remedios, Cris, Konhilas, John, van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 40 KB

english, 2012

24

Training one type of striated muscle to counteract failure of another type

Ger J. M. Stienen, Coen A. C. Ottenheijm

Journal:

The Journal of Physiology

Year:

2012

Language:

english

File:

PDF, 434 KB

english, 2012

25

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients withMYBPC3mutations

Dijk, Sabine J., Boontje, Nicky M., Heymans, Martijn W., Cate, Folkert J., Michels, Michelle, Remedios, Cris, Dooijes, Dennis, Slegtenhorst, Marjon A., Velden, Jolanda, Stienen, Ger J. M.

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2014

Language:

english

File:

PDF, 949 KB

english, 2014

26

Oxidation of Myofilament Protein Sulfhydryl Groups Reduces the Contractile Force and Its Ca 2+ Sensitivity in Human Cardiomyocytes

Hertelendi, Zita, Tóth, Attila, Borbély, Attila, Galajda, Zoltán, van der Velden, Jolanda, Stienen, Ger J.M., Édes, István, Papp, Zoltán

Journal:

Antioxidants & Redox Signaling

Year:

2008

Language:

english

File:

PDF, 238 KB

english, 2008

27

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

Lassche, Saskia, Ottenheijm, Coen AC, Voermans, Nicol C, Westeneng, Henk-Jan, Janssen, Barbara H, van der Maarel, Silvère M, Hopman, Maria T, Padberg, George W, Stienen, Ger JM, van Engelen, Baziel GM

Journal:

Year:

2013

Language:

english

File:

PDF, 209 KB

english, 2013

28

Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction

van Heerebeek, Loek, Hamdani, Nazha, Falcão-Pires, Inês, Leite-Moreira, Adelino F, Begieneman, Mark PV, Bronzwaer, Jean GF, van der Velden, Jolanda, Stienen, Ger JM, Laarman, Gerrit J, Somsen, Aernout

Journal:

BMC Pharmacology and Toxicology

Year:

2013

Language:

english

File:

PDF, 88 KB

english, 2013

29

Impact of Phosphorylation of the Protein Kinase C Sites Ser42/44, Thr143 and Ser199 of Cardiac Troponin I on Myofilament Function in Human Cardiomyocytes

Wijnker, Paul J.M., Foster, D. Brian, Murphy, Anne M., Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 41 KB

english, 2013

30

Reduced Maximal Force and Increased Ca2+-Sensitivity of Human Myofilaments Harbouring the HCM-Associated Cardiac Troponin T Mutation K273N

van Dijk, Sabine J., Dooijes, Dennis, dos Remedios, Cris, Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

31

Protein Kinase Cα Mediated Phosphorylation of Cardiac Troponin Reduces Maximal Force and Exerts Dual Effects on Ca2+-Sensitivity in Human Cardiomyocytes

Kooij, Viola, Piersma, Sander R., Zhang, Pingbo, Boontje, Nicky M., Jiménez, Connie R., Jaquet, Kornelia, dos Remedios, Cris, Murphy, Anne, van Eyk, Jennifer, van der Velden, Jolanda, Stienen, Ger J.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 46 KB

english, 2011

32

Notice from the American Board of Thoracic Surgery

Kooij, Viola, Piersma, Sander R., Tang, Kay W., Jiménez, Conny R., Zang, Pingbo, van Eyk, Jennifer E., Murphy, Anne M., van der Velden, Jolanda, Stienen, Ger J.M.

Journal:

The Annals of Thoracic Surgery

Year:

1979

Language:

english

File:

PDF, 71 KB

english, 1979

33

Identification of Unknown Protein Kinase Cα Phosphorylation Sites on Both Human Cardiac Troponin I and T

Kooij, Viola, Piersma, Sander R., Tang, Kay W., Jiménez, Conny R., Zang, Pingbo, van Eyk, Jennifer E., Murphy, Anne M., van der Velden, Jolanda, Stienen, Ger J.M.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 38 KB

english, 2010

34

Contents

Kooij, Viola, Piersma, Sander R., Tang, Kay W., Jiménez, Conny R., Zang, Pingbo, van Eyk, Jennifer E., Murphy, Anne M., van der Velden, Jolanda, Stienen, Ger J.M.

Journal:

Radiologic Clinics of North America

Year:

2011

Language:

english

File:

PDF, 71 KB

english, 2011

35

Increased Tension Cost in Human Familial Hypertrophic Cardiomyopathy Caused by the MYH7 Mutation R403Q

Witjas-Paalberends, E. Rosalie, Piroddi, Nicoletta, Scellini, Beatrice, Stienen, Ger J., Tesi, Chiara, Pogessi, Corrado, van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

36

Faster Cross-Bridge Relaxation Rates Correlate with Increased Tension Cost in Hcm with the R403Q Myh7 Mutation

Witjas-Paalberends, Rosalie, Ferrara, Claudia, Scellini, Beatrice, Montag, Judith, Stienen, Ger, Kraft, Theresia, Michels, Michelle, Ho, Carolyn, Poggesi, Corrado, van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 53 KB

english, 2014

37

Myosin Binding Protein C Mutations and Hypertrophic Cardiomyopathy: Haploinsufficiency, Deranged Phosphorylation and Cardiomyocyte Dysfunction

van Dijk, Sabine J., Dooijes, Dennis, dos Remedios, Cris, Lamers, Jos M.J., ten Cate, Folkert J., Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

38

Uncovering Effects of the Familial Hypertrophic Cardiomyopathy (fHCM) Related ß-Myosin Mutation Arg723gly in Human Cardiomyocytes

Kraft, Theresia, Boontje, Nicky M., Tripathi, Snigdha, Francino, Antonio, Navarro-López, Francisco, Brenner, Bernhard, Stienen, Ger J., van, Jolanda, Velden, der

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 40 KB

english, 2011

39

Effect of Troponin I Ser23/24 Bis-Phosphorylation on Ca2+-Sensitivity is Dependent on PKA Phosphorylation of Other Contractile Proteins

Kooij, Viola, van der Velden, Jolanda, Stienen, Ger J.M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 61 KB

english, 2009

40

A Novel Mouse Model of Nebulin-Based Nemaline Myopathy

Ottenheijm, Coen, Buck, Danielle, de Winter, Josine, Lawlor, Mike, Stienen, Ger, Beggs, Alan, Labeit, Siegfried, Granzier, Henk

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

41

Myofilament Force Development is Less Economic in Post-Infarct Remodeled Myocardium

van der Velden, Jolanda, Boontje, Nicky M., Merkus, Daphne, Stienen, Ger J.M., Duncker, Dirk J.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 71 KB

english, 2010

42

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

Wijnker, Paul J.M., Sequeira, Vasco, Witjas-Paalberends, E. Rosalie, Foster, D. Brian, dos Remedios, Cristobal G., Murphy, Anne M., Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

43

Impaired Myofilament Contractility in Post-infarct Remodeled Myocardium is Restored upon β-Adrenergic Stimulation

Boontje, Nicky M., Merkus, Daphne, de Beer, Vincent J., Mearini, Giulia, Carrier, Lucie, Walker, Lori A., Stienen, Ger J.M., Duncker, Dirk J., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

44

Rapid Changes in Mitochondrial Ca2+-Concentration in Fast Skeletal Muscle Fibers from Wild Type and Calsequestrin Null Mice

Scorzeto, Michele, Giacomello, Marta, Toniolo, Luana, Canato, Marta, Paolini, Cecilia, Protasi, Feliciano, Reggiani, Carlo, Stienen, Ger J.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 46 KB

english, 2012

45

Nebulin Alters Crossbridge Cycling Kineticis and Increases Thin Filament Activation - a Novel Mechanism for Increasing Tension and Reducing Tension Cost

Ottenheijm, Coen, Chandra, Murali, Mamidi, R., Ford, Steven, Hidalgo, Carlos, Witt, Christian, Stienen, Ger, Labeit, Siegfried, Beggs, Alan, Granzier, Henk

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 86 KB

english, 2010

46

Blunted Length-Dependent Activation Caused by the Homozygous TNNT2 Mutation K280N

Sequeira, Vasco, Wijnker, Paul J.M., dos Remedios, Cris, Stienen, Ger J.M., van der Velden, Jolanda

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 45 KB

english, 2013

47

Cardiomyocyte Hypertrophy and Reduced Myofibril Density Underlie Decreased Maximal Force Generating Capacity in Familial Hypertrophic Cardiomyopathy

Paalberends, Eline R., Stam, Kelly, van Dijk, Sabine J., van Slegtenhorst, Marjon, dos Remedios, Cris, ten Cate, Folkert J.J., Niessen, Hans W.M, Stienen, Ger J.M, Michels, Michelle, van der Velden, J

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

48

Impact of Calsequestrin on the SR Calcium Concentration in Skeletal Muscles Fibers Monitored with a Genetically Encoded Fret Based Indicator

Reggiani, Carlo, Canato, Marta, Scorzeto, Michele, Giacomello, Marta, Protasi, Feliciano, Stienen, Ger J M

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 64 KB

english, 2010

49

The SR Calcium Content of Fast Muscle Fibres Lacking Calsequestrin is Reduced and not Sufficient for Sustained Contractions

Reggiani, Carlo, Stienen, Ger, Quarta, Marco, Canato, Marta, Scorzeto, Michele, Toniolo, Luana, Protasi, Feliciano

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 46 KB

english, 2011

50

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

Manders, Emmy, Bogaard, Harm-Jan, Handoko, M. Louis, van de Veerdonk, Marielle C., Keogh, Anne, Westerhof, Nico, Stienen, Ger J.M., dos Remedios, Cristobal G., Humbert, Marc, Dorfmüller, Peter, Fadel,

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014